Letrozole vs Clomid are both drugs used as a first-line treatment for fertility issues among women. However, since they both count with incredible effectiveness rates related to estrogen control and its related symptoms, they are also used to control other signs of physical and medical issues. Here, you will learn which drug is the best according to your particular needs, which are their prices, how to use them, and many more.
When searching about fertility treatments, the first responders on the subject tends to be Letrozole (Femara) and Clomid (Clomiphene).
However, Clomid is an FDA-approved fertility-related drug that can be prescribed by any first-care physician, it has become the most prescribed fertility treatment for the last 50 years (all these are also due to its effectiveness and low risk of side effects).
Nonetheless, after 2001 Letrozole, an FDA treatment approved mainly to treat breast cancer tumors has found its way through the fertility field, since it can produce superovulation in women thus making it for them easier to get pregnant.
The prescription of Letrozole for fertility issues has been done off-label for female patients that fit the criteria for the treatment. Its effectiveness is bringing more people to choose it over other options.
Despite that Letrozole and Clomid are both being used as the first line of infertility treatment, they are not the same at all.
Their nature, how they work, their results and even their possible side effects are completely different, and they can also vary depending on your previous health condition, age, and sex.
Before going any further in the comparison, we first need to learn what are they and how they influence our organism.
What is Letrozole?
Letrozole, also known as Femara, is the most modern aromatase inhibitor available on the market.
Similar to Arimidex, Letrozole is a potent nonsteroidal AI that can be used along with potent anabolic steroids since it counts with a very strong ability to block the estrogen process.
The main component of Femara’s pills – which is Letrozole – as is the name of the generic drug, interacts to prevent the last step for estrogen synthesis.
This translates in that this chemical interferes with the biosynthetic pathway that allows other hormones – such as testosterone – to convert into estrogen.
Even though it already counts with over 20 years on the market, its effectiveness is related to fighting breast cancer in post-menopausal women thanks to its powerful estrogen-blocking capability, Femar has paved its way to other physical and medical conditions related to this hormone, then again, proving its efficiency.
For example, Femara has shown excellent results related to aiding in fertility issues as a result of the polycystic ovary syndrome.
Letrozole can also help you if you suffer from irregular menstrual cycles, if your progesterone levels are low, or if your menstrual cycles are rare.
Additionally, Femara is now an important part of the Post Cycling Therapy for many bodybuilders and athletes that use anabolic steroids to maximize their gains in lean muscle mass and performance from their heavy training.
A Letrozole’s PCT is important to prevent the apparition of any feminization symptoms, control them or eradicate them if they already appear, and prevent the accumulation of belly fat to keep lean muscle looking hard and dry for upcoming competition; which is why Femara is also widely known as a performance booster.
Lastly, Femar is commonly used to raise testosterone production back to its natural levels among athletes, but also in men that are experiencing fertility issues due to their low testosterone levels.
What is Clomid?
On the other hand, Clomid or also known as its main component the Clomiphene Citrate, it’s a chemical that is classified as a selective estrogen receptor modulator (SERM); which means that it intervenes in the way estrogen is produced and storage by your pituitary gland ¨tricking¨ it to change internal hormone balance.
Clomiphene binds to your brain, make it believe estrogen levels are low and encourages it to make both follicle-stimulating hormone or FSH, and luteinizing hormone, or LH.
Both of these hormones possess important implications for the fertility and performance of both men and women, stimulating not only fertility in both sexes but also acting as a performance booster for an upcoming competition.
Furthermore, here is a list of possible side effects of Letrozole vs Clomid – where you surely can spot more differences -:
Possible side effects of Letrozole
- Weakness and fatigue (this will depend if the person is taking steroids at the time or not; if they are, they won’t suffer from them),
- Nausea, diarrhea, vomiting, heartburn, constipation,
- Joint and muscle aches,
- The swelling of ankles, hands, lower legs, and feet,
- Elevated ¨bad¨ cholesterol levels,
- Hot flashes,
Possible side effects of Clomid
- Abnormal vaginal bleeding
- Multiple births
- Abdominal swelling
- Breast discomfort
- Vision disturbances
- Pelvic pain
According to scientific research, Letrozole was first created as a treatment for breast cancer in post-menopausal women, but, as we mentioned before, physicians are also using it since 2001 as an off-label treatment for infertility, since it counts with fewer side effects than Clomid as well as the fewer risk of multiple pregnancies.
Even though Clomiphene still is the first of a line treatment for infertility cases, studies may differ in how these medications can cause pregnancy.
For example, it seems that Letrozole is more effective for couples suffering from unexplained fertility since its main effect as an aromatase inhibitor is to control estrogen levels that directly affect endometrial development and androgen hormone levels; thus giving them more chances to conceive.
Clomiphene, on the other hand, seems to be more effective in women suffering from polycystic ovary syndrome (PCOS), since this drug alters the estrogen and androgen tissue levels in the pituitary, endometrium, hypothalamus, and ovaries.
Additionally, Femara is also being used as a second option for treatment in women that manifest Clomid resistance – defined as the fact of being unable to experience an increased ovulation activity despite increased doses and after at least three cycles of Clomiphene -.
Clomid, on the other hand, is the leader in fertility treatment for both, men and women, and is an FDA-approved drug for this goal.
Research indicates that Clomiphene causes ovulation in 80% of the cases, thus having optimistic pregnancy rates, and can be an oral treatment for both members of a couple looking to conceive.
In men, Clomid is used as an off-label fertility drug to increase sperm count, and correct any hormonal imbalance that can be interfering with the person’s overall health and wellbeing – let’s keep in mind that low testosterone levels cause erectile dysfunction, loss of muscle mass, hair and libido, fatigue and even mood swings -.
Femara – the brand name of Letrozole – was first created as hormone therapy for postmenopausal women suffering from a certain type of breast cancer.
It can be used to treat:
- Early stages of breast cancer in your lymph nodes
- Locally advanced breast cancer – located near your lymph nodes –
- Metastatic breast cancer
Letrozole can be used on its own or as a side treatment for surgery. Its main effect is to prevent the conversion of androgens and other hormones into estrogen, thus avoiding estrogen-related tumors to grow.
In some cases, Femara’s treatment has reduced cancer tumors effectively.
For pregnancy, Letrozole can be taken in 2.5 milligrams between the third and the seventh day of your menstrual cycle – even though some experts recommend using it from the fifth to the ninth day of it -.
After that, you can start calculating the days in which you will need to have sex in order to conceive:
- If you started Letrozole on the third day, then your ovulation will be between the days 14 to 17 of your cycle. This means that you need to start having sexual relations between the eleventh and the eighteenth day to increase the change to get pregnant
- Conversely, if you begin the treatment on the fifth day, your ovulation will be between days 16 and 19. In this case, you should start having sex every other day from13 to 21
In the case of sports and bodybuilding, athletes welcomed Letrozole thanks to its effectiveness in preventing estrogen conversion via eliminating testosterone interaction with the aromatase enzyme.
This is especially crucial for anabolic steroid cycles in which Femara can prevent gynecomastia and other feminization symptoms such as bloating and high blood pressure.
It has also been proved that Letrozole can reverse the first signs of gynecomastia while helping athletes to keep their gym gains.
To use Femara for bodybuilding, here you have a quick guide:
- Use low doses of 0.5mg to 1mg to control feminization symptoms when doing strong steroid cycles
- Uses a limit dose of 2.5 milligrams from seven to ten days to control and/or eliminate any feminization signs effectively
For the latter, make sure to use high doses for limited amounts of time, since it may drain your energy causing you an excess of fatigue that will affect your training performance.
For men wanting to improve their testosterone levels for fertility goals, Clomiphene treatment goes these ways:
- From 25 milligrams daily for 25 days, with a 5-day break in a 3-month cycle,
- Taking 25 milligrams for 5 days with 5 days off interchanged for three months,
- Or 100-milligram dose for 10 days in one month, for a 3-month cycle
Letrozole vs Clomid takes longer in men to see fertility-related results, which is why it needed to follow a treatment for at least one month to check for any improvements.
As a tip, scientific studies have shown that taking Clomiphene along with Vitamin E or other antioxidant increase the pregnancy rates by 36%.
Women can use Clomiphene not only for infertility but also to treat menstrual cycle abnormalities such as irregular or abnormal periods – periods with no ovulation – as a way to correct possible hormone imbalances.
In case of being taken as a fertility treatment, Clomiphene can be used for Women in these ways:
- 50 milligrams of Clomid between days 3 and 7 of your menstrual cycle, for five continuous days
- As with Letrozole, you can also start between days 5 and 9
You should wait at least a month to see any results. After that, you might want to increase Clomiphene to 100 milligrams or even 150 milligrams – the latter for a very brief period of time, since it increases the chances of developing side effects -.
Which is better Letrozole vs Clomid?
For bodybuilding, Letrozole works best in preventing and reversing gyno signs, which will make your muscles look harder and drier – great for pre-competition conditions -.
Letrozole can also be safely and effectively used for Post Cycle Therapy; however, it can cause an appreciable rise in ¨bad¨ cholesterol levelsthat you should take into consideration to control.
Nonetheless, Femara is preferred for controlling and eliminating early feminization signs, since it is very strong and effective from its very first dosing.
Clomiphene, on the other side, is most popular to bounce back efficiently and fast natural testosterone hormone levels; which makes it stellar for a proper PCT.
Clomid can also act as a performance booster while steroid cycling since it will keep your estrogen levels in control while maintaining or even boosting testosterone production; thus making you be able to produce more lean muscle mass and endurance while training.
Clomid also do marvels in the field of fertility for, men and women, and since it is FDA approved for fertility issues, any first line of treatment physician can prescribe it to you or your partner.
Letrozole is experiencing a rise in the fertility treatment area, but it needs more studies to be fully supported.
Its main advantage is to produce fewer side effects than Clomiphene; but Clomid is cheap and easy to use – as a fertility treatment – and as a selective estrogen receptor modulator or SERM can aid to manage possible hormone imbalances in men and women for biological or training origins.
After giving you all the facts available, is up to you to decide what’s best according to your particular needs or body goals.
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